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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1937 1
1946 2
1947 1
1948 2
1950 2
1951 1
1953 1
1956 1
1957 2
1960 1
1961 1
1962 3
1963 3
1964 3
1965 1
1966 4
1967 4
1968 4
1969 5
1970 4
1971 8
1972 8
1973 12
1974 3
1975 21
1976 36
1977 23
1978 33
1979 40
1980 49
1981 38
1982 65
1983 66
1984 53
1985 98
1986 97
1987 90
1988 106
1989 118
1990 133
1991 145
1992 182
1993 166
1994 181
1995 197
1996 205
1997 245
1998 282
1999 321
2000 338
2001 411
2002 396
2003 483
2004 511
2005 653
2006 696
2007 743
2008 844
2009 843
2010 935
2011 1060
2012 1052
2013 1170
2014 1242
2015 1316
2016 1236
2017 1312
2018 1409
2019 1379
2020 1560
2021 1489
2022 1535
2023 1469
2024 595

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24,978 results

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The following term was not found in PubMed: synoskete
Page 1
Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia.
Bhatt S, Pioso MS, Olesinski EA, Yilma B, Ryan JA, Mashaka T, Leutz B, Adamia S, Zhu H, Kuang Y, Mogili A, Louissaint A Jr, Bohl SR, Kim AS, Mehta AK, Sanghavi S, Wang Y, Morris E, Halilovic E, Paweletz CP, Weinstock DM, Garcia JS, Letai A. Bhatt S, et al. Cancer Cell. 2020 Dec 14;38(6):872-890.e6. doi: 10.1016/j.ccell.2020.10.010. Epub 2020 Nov 19. Cancer Cell. 2020. PMID: 33217342 Free PMC article.
Acquired resistance to BH3 mimetic antagonists of BCL-2 and MCL-1 is an important clinical problem. ...Finally, drug-induced mitochondrial priming measured by dynamic BH3 profiling (DBP) identifies drugs that are persistently active in BH3 mimetic-resistant myelobla …
Acquired resistance to BH3 mimetic antagonists of BCL-2 and MCL-1 is an important clinical problem. ...Finally, drug-induced mitochon …
HDL and Therapy.
Li K, Xie X, Guo Y. Li K, et al. Adv Exp Med Biol. 2022;1377:171-187. doi: 10.1007/978-981-19-1592-5_14. Adv Exp Med Biol. 2022. PMID: 35575930
Based on that, HDL-C has been considered as a promising therapy target to reduce the cardiovascular diseases. Recombinant HDL (rHDL) and apolipoprotein mimetic peptides emerge in recent years and have great potential in the future. ...On the other hand, rHDL not only plays …
Based on that, HDL-C has been considered as a promising therapy target to reduce the cardiovascular diseases. Recombinant HDL (rHDL) and apo …
Membrane Mimetic-Dependence of GPCR Energy Landscapes.
Thakur N, Ray AP, Lyman E, Gao ZG, Jacobson KA, Eddy MT. Thakur N, et al. bioRxiv [Preprint]. 2023 Oct 19:2023.10.16.562552. doi: 10.1101/2023.10.16.562552. bioRxiv. 2023. PMID: 37905159 Free PMC article. Updated. Preprint.
Importantly, the temperature-dependent response of complexes with both full and partial agonists exhibited a pronounced sensitivity to the specific membrane mimetic employed. In striking contrast to observations within lipid nanodiscs, in detergent micelles the active stat …
Importantly, the temperature-dependent response of complexes with both full and partial agonists exhibited a pronounced sensitivity to the s …
Apolipoprotein Mimetic Peptides: Potential New Therapies for Cardiovascular Diseases.
Wolska A, Reimund M, Sviridov DO, Amar MJ, Remaley AT. Wolska A, et al. Cells. 2021 Mar 8;10(3):597. doi: 10.3390/cells10030597. Cells. 2021. PMID: 33800446 Free PMC article. Review.
In this review, we discuss the biochemistry, peptide mimetics design and clinical trials for peptides based on apoA-I, apoE and apoC-II. We primarily focus on applications of peptide mimetics related to cardiovascular diseases. We conclude with a discussion on the l …
In this review, we discuss the biochemistry, peptide mimetics design and clinical trials for peptides based on apoA-I, apoE and apoC- …
Apolipoprotein mimetics in cancer.
Delk SC, Chattopadhyay A, Escola-Gil JC, Fogelman AM, Reddy ST. Delk SC, et al. Semin Cancer Biol. 2021 Aug;73:158-168. doi: 10.1016/j.semcancer.2020.11.002. Epub 2020 Nov 11. Semin Cancer Biol. 2021. PMID: 33188891 Free PMC article. Review.
This review discusses the benefits and mechanism of action of apolipoprotein mimetic peptides in tumor biology and their potential utility in treating various cancers. ...Apolipoprotein mimetic peptides are poorly absorbed when administered orally and rapidly degrad …
This review discusses the benefits and mechanism of action of apolipoprotein mimetic peptides in tumor biology and their potential ut …
Romiplostim.
Kuter DJ. Kuter DJ. Cancer Treat Res. 2011;157:267-88. doi: 10.1007/978-1-4419-7073-2_16. Cancer Treat Res. 2011. PMID: 21052962 Review.
With the discovery and recent clinical availability of thrombopoietin (TPO) mimetics, a new treatment option has emerged. Two TPO mimetics are currently clinically available for treating ITP: romiplostim (an injectable peptide TPO mimetic) and eltrombopag (a …
With the discovery and recent clinical availability of thrombopoietin (TPO) mimetics, a new treatment option has emerged. Two TPO …
Editorial: Exosomes as Therapeutic Systems.
Corradetti B, Gonzalez D, Mendes Pinto I, Conlan RS. Corradetti B, et al. Front Cell Dev Biol. 2021 Jul 21;9:714743. doi: 10.3389/fcell.2021.714743. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34368165 Free PMC article. No abstract available.
Selenium: an insulin-mimetic.
Stapleton SR. Stapleton SR. Cell Mol Life Sci. 2000 Dec;57(13-14):1874-9. doi: 10.1007/PL00000669. Cell Mol Life Sci. 2000. PMID: 11215514 Review.
Insulin or agents that can mimic its action (insulin-mimetics) are necessary to promote the entry of glucose into tissues where the glucose can either be converted into energy or stored for later use. ...This review compares the action of selenium to that of insulin and di …
Insulin or agents that can mimic its action (insulin-mimetics) are necessary to promote the entry of glucose into tissues where the g …
Apolipoprotein A-I mimetics.
Reddy ST, Navab M, Anantharamaiah GM, Fogelman AM. Reddy ST, et al. Curr Opin Lipidol. 2014 Aug;25(4):304-8. doi: 10.1097/MOL.0000000000000092. Curr Opin Lipidol. 2014. PMID: 24977978 Free PMC article. Review.
PURPOSE OF REVIEW: To summarize recent publications in the field of apolipoprotein mimetics. RECENT FINDINGS: Apolipoprotein mimetic peptides continue to show efficacy in a number of animal models of disease and demonstrate properties that make them attractive as po …
PURPOSE OF REVIEW: To summarize recent publications in the field of apolipoprotein mimetics. RECENT FINDINGS: Apolipoprotein mimet …
Hypericin, a potential new BH3 mimetic.
Doroshenko A, Tomkova S, Kozar T, Stroffekova K. Doroshenko A, et al. Front Pharmacol. 2022 Oct 4;13:991554. doi: 10.3389/fphar.2022.991554. eCollection 2022. Front Pharmacol. 2022. PMID: 36267274 Free PMC article.
The viable anti-cancer strategies are based on developing anti-apoptotic Bcl-2 proteins inhibitors, BH3 mimetics. Our focus in past years has been on the investigating a new potential BH3 mimetic, Hypericin (Hyp). ...In combination therapy, low doses of Hyp with Gos …
The viable anti-cancer strategies are based on developing anti-apoptotic Bcl-2 proteins inhibitors, BH3 mimetics. Our focus in past y …
24,978 results
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